Achim Gass1, Steven Smith2, Jochen Hirsch1, Michael Amann1, Matthias Guenther3, Brandon Whitcher4, Michael Chappell2, Anil Rao4, Mark Woolrich2, Mark Sollberger5, Markus Herdener6, Paul M. Matthews4, Andreas U. Monsch6
1Neurology/Neuroradiology, Universitaetsspital Basel, Basel, Switzerland; 2Oxford University Centre for Functional MRI of the Brain (FMRIB), UK; 3mediri GmbH, Germany; 4Imperial College, London and GSK Clinical Imaging Centre, Hammersmith Hospital, UK; 5Neurology, Universitaetsspital Basel, Basel, Switzerland; 6Memory Clinic, Universitaetsspital Basel, Basel, Switzerland
As part of a monocentric biomarker study we investigated 204 subjects (121m 83f, mean age 72 years 50-89 years, healthy elderly (n=61), subjects with dMCI (n=65) and early Alzheimer disease (AD) (n=78). A 60 minutes MRI protocol was developed on a 3T Allegra head only MR system. MRI includes structural, diffusion, ASL perfusion. The difference between NC subjects and patients (AD, MCI) were more pronounced than the difference between MCI subjects and AD patients on global and grey matter atrophy measures, white matter diffusivity measures, and brain perfusion results, while the occipital lobes remain less affected in both AD and MCI.