Abstract #1094

Multiple MRI Measures in the Characterization of Patients with Early Alzheimer Disease or Mild Cognitive Impairment - Relative Sparing of the Occipital Lobes

Achim Gass¹, Steven Smith², Jochen Hirsch¹, Michael Amann¹, Matthias Guenther³, Brandon Whitcher⁴, Michael Chappell², Anil Rao⁴, Mark Woolrich², Mark Sollberger⁵, Markus Herdener⁶, Paul M. Matthews⁴, Andreas U. Monsch⁶

¹Neurology/Neuroradiology, Universitaetsspital Basel, Basel, Switzerland; ²Oxford University Centre for Functional MRI of the Brain (FMRIB), UK; ³mediri GmbH, Germany; ⁴Imperial College, London and GSK Clinical Imaging Centre, Hammersmith Hospital, UK; ⁵Neurology, Universitaetsspital Basel, Basel, Switzerland; ⁶Memory Clinic, Universitaetsspital Basel, Basel, Switzerland

As part of a monocentric biomarker study we investigated 204 subjects (121m 83f, mean age 72 years 50-89 years, healthy elderly (n=61), subjects with dMCI (n=65) and early Alzheimer disease (AD) (n=78). A 60 minutes MRI protocol was developed on a 3T Allegra head only MR system. MRI includes structural, diffusion, ASL perfusion. The difference between NC subjects and patients (AD, MCI) were more pronounced than the difference between MCI subjects and AD patients on global and grey matter atrophy measures, white matter diffusivity measures, and brain perfusion results, while the occipital lobes remain less affected in both AD and MCI.