Abstract #1102

Detection of Changes in Functional Connectivity MRI (FcMRI) Following Aricept Treatment in Subjects with Mild Alzheimers Disease

Shi-Jiang Li¹, Barney Douglas Ward¹, Piero Antuono², Zhilin Wu¹, Jennifer Jones², Thomas McRae³

¹Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA; ²Neurology, Medical College of Wisconsin, Milwaukee, WI, USA; ³Pfizer Inc, New York, NY, USA

A method for global ROI-based functional connectivity MRI (fcMRI) discrimination of Alzheimers (AD) vs. normal healthy (control) study subjects was applied to observe changes in functional connectivity for mild AD study subjects following 3 months of Aricept administration.