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Abstract #1104

Cerebrovascular Disease Associated White Matter Changes in Alzheimers Disease

Liya Wang1,2, Felicia C. Goldstein3, Longchuan Li4, James J. Lah3, Allan I. Levey3 I. Levey3, Hui Mao1

1Department of Radiology, Emory University School of Medicine, Atlanta, GA, USA; 2Department of Radiology, The Second Hospital of Shenzhen, Shenzhen, Guangdong, China; 3Department of Neurology, Emory University School of Medicine; 4Department of Biomedical Engineering, Emory University School of Medicine, Atlanta, GA, USA

This presentation reports a diffusion tensor imaging (DTI) study of white matter changes that may associate to the cerebrovascular disease, a risk factor of Alzheimers Disease (AD). Fractional anisotropy (FA) of the AD patients with and without T2 hyperintense lesions were obtained and compared. AD patients with cerebrovascular disease demonstrated statistically significant decreases in FA values in the right parietal, left frontal and right frontal regions, suggesting that the cerebrovascular disease is closely associated with DTI measured WM changes in AD.