White Matter Abnormality in Dementia with Lewy Bodies: A Diffusion Tensor Imaging Study.

Kuniaki Kiuchi¹, Masayuki Morikawa¹, Toshiaki Taoka², Soichiro Kitamura³, Tomohisa Nagashima¹, Kazumichi Hashimoto¹, Jun Kosaka¹, Yuichiro Inoue¹, Makoto Inoue¹, Kimihiko Kichikawa², Toshifumi Kishimoto¹

Introduction: We investigate white matter using diffusion tensor tractography between subjects with Alzheimerfs disease (AD) and dementia with lewy bodies (DLB). Method: 15 AD, 15 DLB, and 16 controls underwent diffusion tensor tractography. We measured fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values along the nerve bundles in white matter. Result: In the posterior cingulum bundle (PCB) and uncinate fasciculus (UNC), significant differences were observed between AD and controls. DLB exhibited significantly lower FA and higher ADC values in the PCB relative to NC. Conclusion: Subjects with AD and DLB exhibit white matter abnormality relative to controls.