Abstract #1113

High-Resolution Longitudinal Voxel-Based Morphometric Study in ALS

Don Charles Bigler¹, Yaman Aksu², Helen E. Stephens³, Jeffrey Vesek⁴, Kevin R. Scott³, Claire Flaherty-Craig³, Jianli Wang⁴, Paul J. Eslinger^3,4, Zachary Simmons³, Qing X. Yang^4,5

¹Bioengineering, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA; ²Electrical Engineering, Penn State University, University Park, PA, USA; ³Neurology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA; ⁴Radiology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA; ⁵Neurosurgery, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

This work presents results for a longitudinal high-resolution voxel-based morphometric (VBM) study of amyotrophic lateral sclerosis (ALS) using RAVENS images. Images were acquired at baseline, 6 months, and 12 months. A significant negative correlation of gray matter (GM) volume with time was detected in the pre-central gyrus. Negative GM volume correlations were also seen in the superior parietal lobule and the middle temporal gyrus. White matter (WM) volume loss was detected within regions of the parietal lobe and middle temporal lobe. No significant longitudinal volume increases were seen within the ventricles.