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Abstract #1134

Quantitative Susceptibility Imaging of the Rat Brain Using a Dedicated Setup Allowing Different Orientations Along B0

Ludovic de Rochefort1, Tian Liu2, Martine Guillemiller1, Diane Houitte1, Yi Wang2, Philippe Hantraye1, Vincent Lebon1

1MIRCen, CEA-CNRS, Fontenay-aux-roses, France; 2Radiology, Weill Medical College of Cornell University, New York, NY, USA

Neurodegenerative diseases can induce iron metabolism changes. Quantitative susceptibility mapping may be a way to map iron content in the brain. Recently, techniques based on processing the susceptibility induced phases have been developed. This is an ill-posed problem: from the induced magnetic field to the magnetic sources. Specific acquisition and reconstruction techniques are needed such as COSMOS (Calculation Of Susceptibility by Multiple Orientation Sampling) in which several orientations are scanned with respect to B0. Here, a setup is described to rotate rats in vivo and map the field in their brain. Preliminary susceptibility masp demonstrate feasibility.