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Abstract #1157

Measuring Perfusion and Permeability in Multiple Sclerosis: Dynamic Contrast-Enhanced MRI in 3D at 3T

Michael Ingrisch1, Dominik Morhard, Steven Sourbron1, Lisa-Ann Gerdes2, Tania Kmpfel2, Reinhard Hohlfeld2, Maximilian F. Reiser, Christian Glaser

1Josef Lissner Laboratory for Biomedical Imaging, Department of Clinical Radiology, University of Munich - Grosshadern Campus, Munich, Bavaria, Germany; 2Institute for Clinical Neuroimmunology, University of Munich - Grosshadern Campus, Munich, Bavaria, Germany

We propose the use of a fast 3D-view-sharing sequence for dynamic contrast-enhanced MRI in multiple sclerosis (MS) at 3T. This allows for coverage of the whole brain at high spatial and temporal resolution and thus for accurate quantification of perfusion and permeability in MS-lesions using a compartment-modeling approach. We present initial results of a study with 10 patients with relapsing-remitting MS. The results show accurate perfusion metrics for normal-appering white matter (NAWM), clear separation of NAWM and lesions based on the permeability and rather heterogenous vascular perfusion metrics of contrast-enhancing lesions, suggesting a potential for lesion characterization.