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Abstract #1172

Idiopathic Autoimmune Encephalopathy: MR Imaging Appearance

Feng Feng1, Jing Gao2, Hui You1, Ming-Li Li1, Zheng-Yu Jin1

1Radiology, Peking Union Medical College Hospital, Beijing, China; 2Neurology, Peking Union Medical College Hospital, Beijing, China

Although idiopathic autoimmune encephalopathy (AE) is a rare and poorly understood entity, it is becoming increasingly recognized by the association with autoantibody markers and/or clear response to immuno-modulatory treatment. The clinical manifestations of AE are protean and nonspecific, and make the diagnosis challenging. Since AE is a potentially reversible neurological condition, better understanding its MRI appearance is critical to patient’s prognosis. In this study, seven biopsy-proven cases of AE without specific biological markers were described and their MRI findings were suggestive after thorough clinical and laboratory evaluation.