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Abstract #1177

A DTI Study of Structural Integrity of White Matter in Prader-Willi Syndrome

Tianyu Tang1,2, Jennifer L. Miller3, Karen M. von Deneen1, Guojun He1,4, Mark S. Gold1,4, Daniel J. Driscoll3, Yijun Liu1,4

1Psychiatry, University of Florida, Gainesville, FL, USA; 2Key Lab of Child Development and Learning Science, SouthEast University, Nanjing, Jiangsu, China; 3Pediatrics, University of Florida, Gainesville, FL, USA; 4Mcknight Brain Institute, University of Florida, Gainesville, FL, USA

The purpose of this work was to detect white matter abnormalities by using both voxel- and ROI- based methods to compare FA values in DTI of PWS. Eight patients with PWS and eight age- and gender-matched controls were recruited for this study. A number of brain regions such as the thalamus, the extra nuclear, the corpus callosum, the hypothalamus and the right internal capsule were found with a significant reduction in FA values of PWS. The results of this work were relevant to the previous MRI studies and provided more information for the pathology of PWS.