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Abstract #1192

Comparative Evaluation of Corpus Callosum Diffusion Tensor Imaging Metrics in Acute Mild and Moderate Traumatic Brain Injury (TBI): Its Correlation with Neuropsychometric Tests (NPT)

Rakesh K. Gupta1, Raj Kumar2, Mazhar Husain2, Chaynika Chaudhry1, Arti Srivastava1, Sona Saksena1, Ram K.S. Rathore3

1Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2Neurosurgery, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India; 3Mathematics and Statistics, Indian Institute of Technology, Kanpur, Uttar Pradesh, India

Conventional MRI and DTI were performed on 83 patients with mild and moderate TBI within 5-14 days of injury. NPT could only be performed at 6 months of injury. We observed significantly decreased FA in genu and splenium, significantly increased RD in genu, midbody and splenium along with significant increase in MD and decrease in AD only in genu in patients with moderate TBI compared to controls. However, in moderate TBI significantly decreased FA was found only in genu compared to mild TBI and was associated with poorer NPT. We conclude that DTI abnormalities in the regions of corpus callosum was more in patients with moderate TBI compared to mild TBI and was associated with relatively poor neuropsychological outcome.