Maurcio S. Sercheli1, Elizabeth Bilevicius2, Helka Ozelo1, Andra Alessio2, Fabricio RS Pereira2, Jane M. Rondina2, Tatiane Pedro2, Fernando Cendes2, Roberto JM Covolan1
1Neurophysics Group, Institute of Physics Gleb Wataghin, University of Campinas - UNICAMP, Campinas, SP, Brazil; 2Laboratory of Neuroimaging, Faculty of Medical Sciences, University of Campinas - UNICAMP, Campinas, SP, Brazil
We have studied thirty two patients with mesial temporal lobe epilepsy by simultaneous electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI), aiming to investigate the spatial correspondence between epileptiform spikes and BOLD responses. All patients have hippocampus atrophy and were under clinical investigation during the last five years. The average exam time of 42 minutes per patient presented an average IED of 14. This study has shown an elevate rate of effective BOLD responses associated with focal epileptic activity. In 40% of the cases a good spatial agreement has been found among previous clinical investigation and positive BOLD responses.
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