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Abstract #1204

Can FMRI Replace Wada in Pre-Surgical Evaluation of Language Dominance?

Madalina Elena Tivarus1,2, John T. Langfitt3, Derek D. Lasher4, Sven Ekholm1

1Department of Imaging Sciences, University of Rochester, Rochester, NY, USA; 2The Rochester Center for Brain Imaging, University of Rochester, Rochester, NY, USA; 3Epilepsy Center, University of Rochester, Rochester, NY, USA; 4Skidmore College, Saratoga Springs, NY, USA

FMRI is becoming an increasingly viable alternative to what has been the gold standard for functional lateralization, Wada procedure. There are great challenges when performing these exams in individual patients since there is no standardized procedure and patterns of activation differ widely between patients. Our retrospective study found that fMRI using a battery of language tests is more reliable than a single test in assessing language hemispheric dominance in patients with brain lesions and/or epilepsy. However, the technique is not yet able to entirely replace the Wada procedure but can be used as a screening tool to limit its need.