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Abstract #1214

Adaptation of the Visual Cortex in Response to Cataract Surgery

Astrid Rosenstand Lou1,2, Hanne Olsen Julian2, Jan Ulrik Prause3, Troels Wesenberg Kjr4, Olaf B. Paulson1, Kristoffer Hougaard Madsen1

1Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 2Eyeclinic, Rigshospitalet, Copenhagen, Denmark; 3Eye Pathology Institute, Rigshopitalet, Copenhagen, Denmark; 4Clin. Neurophysiology, Rigshospitalet, Copenhagen, Denmark

We aim to investigate the plasticity in the normal aging brain in response to an abrupt change in vision. 15 subjects with senile cataract were followed by fMRI before cataract surgery, 2 days after surgery and 6-8 weeks after surgery. Results show a tendency that the difference in BOLD activation resulting from stimulation of the operated and non-operated eye decrease over time.