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Abstract #1220

Metabolite T2 Relaxation Abnormalities in Bipolar Disorder and Schizophrenia

David P. Olson1, J. Eric Jensen1, Andrew P. Prescot1, Elixabeth D. Rouse1, Bruce M. Cohen1, Perry F. Renshaw2, Dost ngr1

1McLean Hospital, Belmont MA and Harvard Medical School, Boston MA, Belmont, MA, USA; 2The Brain Institute, University of Utah, Salt Lake City, UT, USA

We present results showing that brain metabolite T2 relaxation times, long assumed to be relatively constant in MRS based studies of neuropsychiatric disorders, are in fact significantly different in bipolar and schizophrenic subjects compared with healthy controls. These metabolite T2 relaxation measurements may serve as a useful probe to help characterize the cellular microenvironment in these disorders.