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Abstract #1222

Disrupted White Matter Connectivity Revealed by Diffusion Tensor Imaging in Children with Tourette Syndrome

Xiaoqi Huang1, Jinhua Sun2, Xiu Li Li1, Fei Li1, Mingjing Huang2, Lanting Guo2, Qiyong Gong1

1Huaxi Magnetic Resonance Research Centre, Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China; 2Department of psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, China

Tourette syndrome(TS) is a childhood-onset neurobehavioral disorder characterized by motor and vocal tics and structural and functional disruption of cortico-striato-thalmo-cortical (CSTC) circuits had been suspected as core pathophysiology for the disease. Present study aimed at exploring the brain white matter abnormality in children with TS by DTI in a whole brain voxel-wise base and then deepening the exploration to fiber tracks. Compared with normal controls, significant reductions of FA value in TS patients were found most obviously in bilateral middle cerebellar peduncle(MCP), bilateral posterior limbs of internal capsule(PLIC).