A DTI Tractography Study of the Cingulum in Euthymic Bipolar I Disorder

Louise Emsell¹, Alexander Leemans², Camilla Langan¹, Gareth Barker³, Wilhelm van der Putten¹, Peter McCarthy¹, Rachel Skinner¹, Colm McDonald¹, Dara M. Cannon¹

This preliminary analysis identified inter-hemispheric differences in FA of the cingulum bundle in control (n=19) and euthmyic bipolar I disorder subjects (n=15; Left > Right). However, mean of the median FA and ADC values did not differ between these groups in the left or right cingulum bundle. We employed steamline DTI tractography using ExploreDTI for this analysis. FA did correlate with age in the right cingulum consistent with the finding of previously published studies. Future plans include expanding the sample size and exploring more anatomically specific sub-regions of the cingulum bundle in bipolar disorder versus controls.