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Abstract #1227

A Diffusion Tensor MRI Study of White Matter Microstructure in Tardive Dyskinia: Relation to Symptoms

Kun-Hsien Chou1, I-Yun Chen2, Ya-Mei Bai3, Tung-Ping Su3, Woei-Chyn Chu1, Ching-Po Lin2,4

1Institute of Biomedical Engineering, National Yang Ming University, Taipei, Taiwan; 2Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan; 3Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; 4Institute of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan

Tardive dyskinesia (TD), the most severe side effect of antipsychotics, is characterized by late-onset, repetitive involuntary choreiform movement, tics and grimaces of the orofacial muscles, and dyskinesia of the distal limbs. Pervious studies have suggested that schizophrenic patients with TD had an excess of neurodevelopmental disturbance, particularly minor physical anomalies, in association with cognitive dysfunction and abnormalities of cerebral structure. In this research, voxel-wised DTI analysis was performed to investigate the differences among schizophrenia with/without TD and healthy controls. Relationship between clinical symptom and WM microstructure abnormality were also examined.