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Abstract #1235

Volume and Shape Analysis of the Caudate in ADHD Adults

Karlene M. Fraser1, Ruth L. O'Gorman2, Laura A. Wherity3, Philip J. Asherson4, Brian Toone4, Mitul A. Mehta5

1Neuroimaging, Maudsley Hospital, London, UK; 2Neuroradiology, King's College Hospital, London, UK; 3Medical Engineering and Physics, King's College Hospital, London, UK; 4Neuropsychiatry unit, Maudsley Hospital, London, UK; 5Centre for Neuroimaging Sciences, Institute of Psychiatry, London, UK

Neuro-developmental differences between 10 adult patients with attention deficit hyperactivity disorder (ADHD) and 17 age-matched controls were investigated using caudate volume and shape analysis. Both groups demonstrated significant laterality differences in caudate volume, surface area, and surface area to volume (SA/V) ratio. While no significant differences in caudate volume and surface area were observed between groups, the ADHD group displayed a significantly higher SA/V ratio on the right. Significant correlations emerged between hyperactivity/impulsivity symptom scores and caudate SA/V ratio in the unmedicated ADHD patients, suggesting that ADHD symptoms are associated with neuroanatomical differences in caudate development.