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Abstract #1259

Effect of Recurrent Isoflurane Anaesthesia During Development on the Neurochemical Profile of the Frontal and Occipital Cortex of Adult Mice: An in Vivo 1H MRS Study at 14.1 T

João MN Duarte1, Anita Frank2, Kim Q. Do2, Rolf Gruetter1,3

1Centre d'Imagerie BioMedicale, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland; 2Schizophrenia Research Unit, Center for Psychiatric Neuroscience, Univ. Hosp. Lausanne, Lausanne, Switzerland; 3Departments of Radiology, Universities of Lausanne and Geneva, Switzerland

The in vivo NMR scanning of animals at different stages of development requires recurrent anaesthesia. The present study investigated whether recurrent isoflurane anaesthesia during development has an effect on the cortical neurochemical profile of the adult mice.