Abstract #1261

Quantitative Assessment of Prenatal X-Ray Exposure Using Longitudinal Gadolinium-, Manganese-Enhanced and Perfusion MRI in Neonatal Rats

Shigeyoshi Saito¹, Kazuhiko Sawada², Xue-Zhi Sun³, Tetsuya Suhara⁴, Iwao Kanno⁴, Ichio Aoki⁴

¹Department of Molecular and Neuroimaging, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan; ²Laboratory of Anatomy, Department of Physical Therapy, Faculty of Medical and Health Sciences, , Japan; ³Regulation Science Research Group, National Institute of Radiological Sciences, Chiba, Japan; ⁴Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan

In vivo evaluation of radiation damage in the CNS is important for the assessment and treatment. Our goal is to investigate differences in the longitudinal dynamics between normal and irradiated subjects using Gd-DTPA, Mn2+ T1 agents, and perfusion imaging (EPI-FAIR). In addition, the contribution of the BBB permeability was tested between 1-week neonatal and 2-week rats. Gd-DTPA and perfusion MRI is a useful technique for BBB and microcirculation assessment in subjects exposed to ionizing radiation. Mn2+ contrast agents used in conjunction with T1 mapping can be used as a cellular density/activity indicator for a neonatal animal.