Anqi Qiu1, Deana Crocetti2, Michael I. Miller3, Steward H. Mostofsky2
1Division of Bioengineering, National
University of Singapore, Singapore, Singapore; 2Department of
Developmental Cognitive Neurology, Kennedy Krieger Institute, Baltimore, MD,
USA; 3Biomedical Engineering, Johns Hopkins University, Baltimore,
We introduce an automatic shape analysis approach under large deformation diffeomorphic metric mapping (LDDMM) framework for studying subcortical shape abnormalities associated with neurodegenerative and neuropsychiatrc diseases. The approach was applied to investigating basal ganglia shapes in children with Autism. Our results revealed no volume differences but remarkable shape abnormalitis of the basal ganglia in children with Autism. The shape abnormal pattern indicates that Autism involves not only one neuronal circuit.