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Abstract #1271

Analysis of Superior Longitudinal Fasciculus and Arcuate Fasciculus with Diffusion Tensor Images of Dyslexia Patients

Hao Huang1,2, Jonathan M. Chia3, Michael C. Morriss2,4, Zhiyue J. Wang2,4, Barjor Gimi2,4, Nancy K. Rollins2,4

1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, USA; 2Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA; 3Philips Healthcare, Dallas, TX, USA; 4Radiology, Children's Medical Center, Dallas, TX, USA

Dyslexia manifests primarily as a difficulty with written language. Fractional anisotropy (FA) derived from DTI can be used to detect the subtle structural white matter abnormalities. In this study, superior longitudinal fasciculus (SLF) and arcuate fasciculus (AF) of control and dyslexia groups were segmented with DTI-based tractography. AF was divided into smaller segments for detecting local FA changes. There is no statistically significant difference of averaged FA of the whole tract. However, the FA at posterior portion of frontal part of AF is significantly smaller in dyslexia children, so are the relative volumes of total SLF and AF.