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Abstract #1275

Manganese - Gold Nanospheres as Positive Contrast Agents for Magnetic Resonance Imaging (MRI)

Stephanie Jacobs1, Simona Murph2, Matthew Siegfried2, Steven Serkiz2, Tom Chih-Chuang Hu1

1Small Animal Imaging, Medical College of Georgia, Augusta, GA, USA; 2Savannah River National Laboratory, Aiken, SC, USA

Gold (Au) nanoparticles are of interest to medical researchers for their: tunable physicochemical properties, ability to bind to cell markers, and near-IR absorption and associated local heating. Manganese (Mn) Au nanospheres were synthesized by adding MnCl2 to a suspension of citrate capped Au nanospheres. The nanospheres were added to cells that were then imaged using MRI. This study shows the possibility of cellular uptake of the Mn Au nanosphere clusters. The cells appear to uptake and retain more manganese at concentrations from 0.4 - 0.5 mM. Ex vivo MRI measurements showed a T1 enhancement of nanoparticles within the cells.