Abstract #1283

Morphological Study of Mouse Brain Models with Down Syndrome Using MEMRI

Bich-Thuy Doan¹, Eva Toth¹, Ahmad Almhdie², Patricia Lopes-Pereira³, Paulo Loureiro de Sousa^1,4, Sandra Meme¹, Frdric Szeremeta¹, Caroline Colombier³, Vronique Brault³, Christophe Leger², Roger Ledee², Rachid Harba², Yann Herault³, Jean-Claude Beloeil¹

¹CBM, CNRS, Orlans, France; ²Institut PRISME, Universit d'Orlans, Orlans, France; ³IEM, CNRS, Orlans, France; ⁴Institut de Myologie, AIM, Paris, France

Our aim is to develop new models of human chromosome 21 aneuplodies and a 3D segmentation software using MEMRI at 9.4T. We studied Ts1Yah, Ts2Yah, Ts65Dn and Tg(Pcp4) trisomic models mice. We developed a powerful tool in order to perform an automatic segmentation and 3D reconstruction of three brain subregions (whole brain, hippocampus, cerebellum). MEMRI makes it possible to obtain at high magnetic field morphological images with strong contrast. A semi-automatic quantitative study has been performed in comparison to manual method. Volumes were comparable statistically, but processing time was drastically reduced, and segmentation quality and accuracy were improved.