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Abstract #1283

Morphological Study of Mouse Brain Models with Down Syndrome Using MEMRI

Bich-Thuy Doan1, Eva Toth1, Ahmad Almhdie2, Patricia Lopes-Pereira3, Paulo Loureiro de Sousa1,4, Sandra Meme1, Frdric Szeremeta1, Caroline Colombier3, Vronique Brault3, Christophe Leger2, Roger Ledee2, Rachid Harba2, Yann Herault3, Jean-Claude Beloeil1

1CBM, CNRS, Orlans, France; 2Institut PRISME, Universit d'Orlans, Orlans, France; 3IEM, CNRS, Orlans, France; 4Institut de Myologie, AIM, Paris, France

Our aim is to develop new models of human chromosome 21 aneuplodies and a 3D segmentation software using MEMRI at 9.4T. We studied Ts1Yah, Ts2Yah, Ts65Dn and Tg(Pcp4) trisomic models mice. We developed a powerful tool in order to perform an automatic segmentation and 3D reconstruction of three brain subregions (whole brain, hippocampus, cerebellum). MEMRI makes it possible to obtain at high magnetic field morphological images with strong contrast. A semi-automatic quantitative study has been performed in comparison to manual method. Volumes were comparable statistically, but processing time was drastically reduced, and segmentation quality and accuracy were improved.