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Abstract #1287

Segmentation and Calculation of Stroke- And Manganese-Enhanced Volumes After Reconstruction of the Injured Hemisphere in the Hypoxic-Ischemic Neonatal Rat Brain

ystein Olsen1, Marius Widere2, Pl Erik Goa3,4, Jon Skranes2,5, Ann-Mari Brubakk2,5, Christian Brekken3

1Department of Radiography, Sr-Trndelag University College, Trondheim, Norway; 2Department of Laboratory Medicine, Childrens and Womens Health, University of Science and Technology, Trondheim, Norway; 3Department of Circulation and Medical Imaging, Norwegian University of Science and Technology,, Trondheim, Norway; 4Department of Radiology, St Olavs Hospital, Trondheim, Norway; 5Department of Pediatrics, St Olavs Hospital, Trondheim, Norway

The injured brain hemisphere was reconstructed based on the segmented non-injured intracranial volume and non-injured brain hemisphere. Animals with no Hypoxic-Ischemic injury (HI) were used for validation and a non-significant mean difference of 1.3% between the segmented and reconstructed hemisphere volumes was detected. This indicated a good correspondence between the direct segmented and reconstructed hemisphere. The semi-automatic method developed for this task enables calculation of absolute and relative stroke- and ME volumes and can be used for in vivo longitudinal study of HI development and associated manganese enhancement.