Jieun Kim1, In-Young Choi1,2, Elias K. Michaelis3, Sang-Pil Lee1,4
1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, USA; 2Department of Neurology, Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA; 3Department of Pharmacology and Toxocology, University of Kansas, Lawrence, KS, USA; 4Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA
Alcoholism is one of the major health problems in our population. The glutamate system has been implicated as a primary target of the actions of ethanol. This study aims to investigate the possible changes axonal transport in hyperglutametergic transgenic mice (Glud1-tg) with ethanol treatment using manganese-enhanced MRI (MEMRI). Our results show that axonal transport rates in Glud1-tg mice were significantly lowered following ethanol treatment.
Keywords