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Abstract #1299

Preclinical Screening of a Potential Drug Treatment for Spinal Cord Injury Using Magnetic Resonance Imaging

Peter Cheng-te Chou1, Mehmet Levend Gunsoy1, Mohamed Mokhtar Desouki1, Shunmugavel Anandakumar1, Musfiquddin Khan1, Hanaa El Sayed1, Shaun Nguyen1, Inderjit Singh1, Mehmet Bilgen1

1Medical University of South Carolina, Charleston, SC, USA

Potential new therapies for treating spinal cord injury (SCI) are currently being developed and tested in animal models. The modulator of cellular redox, S-nitrosoglutathione (also known as GSNO) has shown to prevent endothelial dysfunction, facilitate neuroprotection and repair, and promote locomotor function during recovery following neuronal injury. Evaluating the efficacy of a pharmacological treatment, such as GSNO, depends on accurately quantifying drug-induced improvements in neuropathological state of injured spinal cord (SC). In this study, we use magnetic resonance imaging (MRI) for evaluating the efficacy of GSNO in SCI in a rat model.