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Abstract #1345

Novel Combination Therapy of Recombinant Annexin 2 and Low Dose Recombinant Tissue Plasminogen Activator in Embolic Rat Stroke Model: A Magnetic Resonance Imaging Study

Yoji Tanaka1, Tsukasa Nagaoka1, Govind Nair1, Qiang Shen1,2, Xiaodong Zhang1, Timothy Q. Duong1,2

1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA; 2Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA

In the treatment of acute phase ischemic stroke, tPA has high risk of hemorrhage which is usually fatal, and the treatment time window is very narrow. The aim of this study is to examine a novel combination therapy of recombinant annexin 2 and low dose rtPA for acute ischemic stroke with employing MRI. We conclude that the combination therapy has a possibility to reduce the harmful side effect of rtPA without reducing its benefits as treatment.