Meeting Banner
Abstract #1358

Understanding the Recuded ADC in Stroke Lesions Using Repeated Measurements with Different Diffusion Times

Markus Nilsson1, Jimmy Ltt2, Danielle van Westen2, Stig Holts2,3, Ronnie Wirestam1, Freddy Sthlberg1,3, Sara Brockstedt2

1Department of Medical Radiation Physics, Lund University, Lund, Sweden; 2MR Department, Center for Medical Imaging and Physiology, Lund University Hospital, Lund, Sweden; 3Department of Diagnostic Radiology, Lund University, Lund, Sweden

The mechanism behind the reduction of the apparent diffusion coefficient (ADC) in ischaemic stroke is as yet unclear. Effects of water exchange have recently been observed in sub-acute stroke lesions, based on measurements with high b-values and a varied diffusion time. Here we repeated such measurements in two patients, three and ten days after stroke onset. The presence of water exchange was verified. The intracellular signal fraction decreased as the time from the stroke-onset increased and we found indications of different relaxation times in the intra- and extracellular space in the stroke lesions.