Benjamin Hoff1, Denis Le Bihan2, Alnawaz Rehemtulla3, Thomas Chenevert1, Brian Ross1, Craig Galbn1
1Radiology, University of Michigan, Ann
Arbor, MI, USA; 2NeuroSpin, CEA, Saclay, France; 3Radiation
Oncology, University of Michigan, Ann Arbor, MI
Diffusion MRI at low b-values (~1000 s/mm2) has shown promise as an early surrogate biomarker of treatment response in glioma patients. Recent studies have shown that at higher b-values (>3000 s/mm2) signal attenuation by diffusion deviates from monoexponential behavior in biological tissue. The aim of this study was to test the response of the apparent diffusion coefficient (ADC) calculated from various non-monoexponential models against a conventional two-point low b-value method following chemotherapy in a rodent brain tumor model.