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Abstract #1414

Polyvinylpyrrolidone (PVP) Water Solutions as Isotropic Phantoms for Diffusion MRI Studies

Carlo Pierpaoli1, Joelle Sarlls1, Uri Nevo1,2, Peter J. Basser1, Ferenc Horkay1

1NIH, Bethesda, MD, USA; 2Department of Biomedical Engineering, Tel-Aviv University, Tel-Aviv, Israel

In this work we characterize the diffusion behavior of aqueous solutions of PVP as candidates for a non-toxic diffusion MR phantom suitable for use in a clinical setting. We find that PVP solutions have desirable characteristics. They have temporal stability, show gaussian diffusion profiles, and cover the large range of diffusivities observed in human tissues.