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Abstract #1428

Between-Scanner Variation in Normal White Matter ADC in the Setting of a Multi-Center Clinical Trial

Jing Huo1, Matthew S. Brown1, Jeffry R. Alger1,2, Hyun J. Kim3, Whitney B. Pope3, Jonathan G. Goldin3

1Department of Radiological Sciences , UCLA, Los Angeles, CA, USA; 2Department of Neurology, UCLA, Los Angeles, CA, USA; 3Department of Radiological Sciences, UCLA, Los Angeles, CA, USA

The aim was to study the between-scanner variation and the scan-rescan variation of normal brain white matter apparent diffusion coefficient (ADC) measurements in the setting of multi-center chemotherapy clinical trial for glioblastoma multiforme which used different scanner models. Measured baseline BWM ADC values were consistent across six different scanner models from two manufacturers but ADC coeeficient of variation did vary between scanner models. The scanners showed no difference in their ability to reproduce BWM ADC measurement from the same patient on two successive visits.