Abstract #1433

Evolution of Diffusion Tensor Parameters After Permanent Experimental Stroke in Rats

Miia Pitkonen^1,2, Usama Abo-Ramadan^1,2, Eric Pedrono^1,2, Ivan Marinkovic^1,2, Daniel Strbian^1,2, Aysan Durukan^1,2, Turgut Tatlisumak^1,2

¹Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland; ²Experimental MRI Laboratory, Biomedicum Helsinki, Helsinki, Finland

In the present work, the temporal evolutions of the diffusion tensor imaging (DTI) parameters (fractional anisotropy (FA) and rotationally invariant apparent diffusion coefficient (ADC)) were measured after permanent middle cerebral artery occlusion (MCAO). Wistar rats (n=9) were subjected to focal cerebral ischemia. They were imaged at 2 and 3.5 hours, 1, 2, 3, and 4 days, 1, 2, 4, 6, and 8 weeks. The MRI measurements were performed with a 4.7 T MR Scanner. This study showed that, after permanent MCAO, there are differences in the temporal evolution of FA in different brain tissues.