Abstract #1437

Diffusion Simulation Tractography for High Angular Resolution Diffusion Imaging

Ning Kang¹, Gregory T. Balls¹, Lawrence R. Frank^1,2

¹Center for Scientific Computation in Imaging, University of California San Diego, La Jolla, CA, USA; ²Radiology Department, VASDHS, San Diego, CA, USA

Regions of complex fiber architecture in the presence of multiple fiber orientations within a single voxel are common in the brain and pose a significant problem for standard DTI (Diffusion Tensor Imaging) based fiber tracking methods, therefore limit the utility of HARDI (High Angular Resolution Diffusion Imaging) acquisition techniques. Here we propose an extension of our previously demonstrated diffusion simulation tractography method to HARDI technique that has potentials to overcome these limitations and thus provide more information about connectivity in the brain.