Abstract #1480

Intravascular Water Molecule Lifetime in the Japanese Macaque Brain

Jeffrey Moses Njus¹, James R. Pollaro¹, Mathew T. Snodgrass¹, John Cunneen¹, Ethan Muldoon¹, Vincent B. Warren², Xin Li¹, Charles S. Springer¹, Steven G. Kohama², William D. Rooney¹

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, USA; ²Oregon National Primate Research Center, Beaverton, OR, USA

The purpose of this study was to investigate brain intravascular water molecule lifetime estimation using a dynamic contrast enhanced technique. MRI data were collected at 3T in the Japanese macaque. Gadoteridol (Gd) was administered and whole-brain quantitative R₁ maps were collected using a sparse pharmacokinetic temporal sampling scheme during the contrast washout period. We compare intravascular water lifetimes extracted with and without accounting for Gd extravasation during the time series.