Meeting Banner
Abstract #1480

Intravascular Water Molecule Lifetime in the Japanese Macaque Brain

Jeffrey Moses Njus1, James R. Pollaro1, Mathew T. Snodgrass1, John Cunneen1, Ethan Muldoon1, Vincent B. Warren2, Xin Li1, Charles S. Springer1, Steven G. Kohama2, William D. Rooney1

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, USA; 2Oregon National Primate Research Center, Beaverton, OR, USA

The purpose of this study was to investigate brain intravascular water molecule lifetime estimation using a dynamic contrast enhanced technique. MRI data were collected at 3T in the Japanese macaque. Gadoteridol (Gd) was administered and whole-brain quantitative R1 maps were collected using a sparse pharmacokinetic temporal sampling scheme during the contrast washout period. We compare intravascular water lifetimes extracted with and without accounting for Gd extravasation during the time series.