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Abstract #1483

Accuracy of Cerebral Blood Flow Measurements in Accelerated Dynamic Contrast Enhanced MRI Using k-T SENSE

Henrik Pedersen1, Adam Espe Hansen1, Henrik B.W. Larsson1

1Functional Imaging Unit, Glostrup Hospital, Glostrup, Denmark

Dynamic contrast enhanced (DCE) MRI represents an attractive technique for quantifying cerebral blood flow (CBF). However, the inherent slow nature of DCE-MRI currently prohibits whole-head imaging of CBF. This study investigates how different degrees of data reduction obtained with k-t SENSE influence CBF measurements in the brain. The results suggest that the optimum combination of training data size and acceleration factor is 11 training profiles and 8x acceleration, resulting in a net acceleration factor of 4.6. In practise, this allows increasing the spatial coverage of DCE-MRI from 4 slices with SENSE to 10 slices with k-t SENSE.