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Abstract #1487

Single-Shot Look Locker T1 Mapping with Golden Angle Radial Sampling for Free-Breathing Liver DCE-MRI in Rats at 1.5 T

Andreas Steingoetter1, Jonas Svensson1,2, Rickmer Braren3, Rene Botnar1,4, Stefanie Remmele5

1Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitt Mnchen, Munich, Germany; 2Department of Medical Radiation Physics, Malmoe University Hospital, Lund University Malmoe, Malmoe, Sweden; 3Department of Radiology, Klinikum rechts der Isar, Technische Universitt Mnchen, Munich, Germany; 4Division of Imaging Sciences, Kings College London School of Medicine, London, UK; 5Philips Research Europe-Hamburg, Hamburg, Germany

A 2D single-shot Look-Locker T1 mapping technique (LLRGC) applying golden angle radial sampling and dedicated contrast enhancing k-space filter has recently been proposed for DCE-MRI studies. Here, we evaluate this technique for non-triggered and free-breathing DCE-MRI experiments in rats. T1 variability, flip angle dependency and motion sensitivity were analyzed in-vitro and in-vivo. Modelling capability of acquired concentration curves was confirmed by calculating Ktrans and ve. Phantom T1 values match reference values and show no flip angle dependency. No impairing motion artefacts are observed in images and T1 maps of rat abdomen. Determined Ktrans and ve values correspond to literature values.