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Abstract #1497

Crossing Fibers in Lateral White Matter of the Cervical Spinal Cord Detected with Diffusion MRI in Monkey Postmortem

Henrik Lundell1,2, Tim Dyrby1, Maurice Ptito1,3, Jens Bo Nielsen4

1Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Copenhagen, Denmark; 2Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, France, Denmark; 3School of Optometry, Univ Montreal, Montreal, QC, Canada; 4Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark


Mapping the white matter configuration of the spinal cord is of interest for understanding superspinal contribution to the generation of motion and coordination of muscles. Postmortem diffusion weighted MRI is a potent technique to investigate the microstructure of neuronal tissue. We have investigated fiber directions of the spinal cord in monkey using DT, Q-ball and PAS. Crossing fiber structures in the corticospinal tract was found using multi-fiber reconstruction techniques with good correlation to histological findings of terminating fibers.