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Abstract #1499

Temporal Tissue Assessment in Non-Human Primate Cerebral Ischemia Using Diffusion-Weighted MR Imaging and ISODATA Cluster Analysis

Mark J.R.J. Bouts1,2, Ona Wu1,3, Rick M. Dijkhuizen2, Alex J. de Crespigny1,3, Helen E. D'Arceuil1,3

1Athinoula A. Martinos center for biomedical imaging, Massachusetts General Hospital, Charlestown, MA, USA; 2Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 3Radiology, Massachusetts General Hospital, Charlestown, MA, USA

Non-human primate experimental stroke models allow for studying precisely timed evolutionary DWI stroke patterns, which appear similar to those seen in human stroke, without temporal MRI sampling restriction. In regional analysis partial volume artifacts and non-significant regional signal variations within the lesions can bias the analysis outcome.Therefore, in this study we applied an ISODATA analysis to elucidate on a voxel-by-voxel basis multiple evolutionary ADC/FA signatures in permanent vs transient MCA occluded macaque brains. Five distinct signatures were distinguished demonstrating the potential of voxel-by-voxel analysis in staging, identifying and quantifying ischemic tissue damage as a result of stroke.