ABCDEFGHI: Anatomic Basis Construction for Dynamic Enhancement Following Gadolinium CHelate Injection

Dustin K. Ragan¹, James A. Bankson¹

Dynamic Contrast Enhaced (DCE) MRI measures the time course of a contrast agent in blood and tissue to investigate microvasculature. The measurement in the blood is challenging, particularly in small animal models, because of the small size of blood vessels and the fast kinetics of the agent in the bloodstream. We have developed a novel reconstruction technique which permits reconstruction of the signal in a ROI from a single phase encode line. Using this technique we have performed high temporal resolution measurements of the blood time course in the heart which are free of partial volume effects.