Abstract #1511

Reliable Isolation of the Intravascular Contribution in Arterial Spin Labelling MRI

Michael A. Chappell¹, Bradley J. MacIntosh¹, Nicola Filippini^1,2, Matthias Gnther^3,4, Clare E. Mackay^1,2, Peter Jezzard¹, Mark W. Woolrich¹

¹Centre for Functional MRI of the Brain, University of Oxford, Oxford, UK; ²Department of Psychiatry, University of Oxford, UK; ³Univeristy Hospital Mannheim, University of Heidelberg; ⁴Advanced MRI Technologies, Sebastopol, CA

Multi-inversion time ASL is a potentially rich source of information about the cerebral blood flow, providing more than just CBF measurement alone. This study demonstrates that it is feasible to extract the intravascular contribution in ASL data that has not been subject to flow suppression. A probabilistic approach is used that allows Automatic Relevancy Determination to be implemented, avoiding over fitting with an arterial blood signal where none exists.