Xiufeng Li1, Subhendra Sarkar2, David M. Buhner3, Robert W. Haley4, Richard W. Briggs3,5
1Biomedical Engineering, UT Southwestern Medical Center, Dallas, TX, USA; 2Radiology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 3Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA; 4Internal Medicine, UT Southwestern Medical Center , Dallas, TX, USA; 5Radiology, UT Southwestern Medical Center, Dallas, TX, USA
To better facilitate hippocampus physostigmine challenge perfusion studies using ASL technique, one optimization study was performed to determine proper post-bolus delay time by performing multiple inversion perfusion studies with fixed labeling time but varied post-bolus delay times for sessions with both saline infusion and PHY infusion. The study results indicate that post-bolus delay times equal to 1.0 s or 1.2 s give lower inter-subject variability of hippocampus CBF measurements for perfusion studies with both saline and PHY challenge. Hippocampus CBF measurements at post-bolus delay equal to 1.2 s showed the largest decrease in CBF with PHY infusion.
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