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Abstract #1516

ASL Optimization for Hippocampus Physostigmine Challenge Perfusion Study

Xiufeng Li1, Subhendra Sarkar2, David M. Buhner3, Robert W. Haley4, Richard W. Briggs3,5

1Biomedical Engineering, UT Southwestern Medical Center, Dallas, TX, USA; 2Radiology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 3Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA; 4Internal Medicine, UT Southwestern Medical Center , Dallas, TX, USA; 5Radiology, UT Southwestern Medical Center, Dallas, TX, USA

To better facilitate hippocampus physostigmine challenge perfusion studies using ASL technique, one optimization study was performed to determine proper post-bolus delay time by performing multiple inversion perfusion studies with fixed labeling time but varied post-bolus delay times for sessions with both saline infusion and PHY infusion. The study results indicate that post-bolus delay times equal to 1.0 s or 1.2 s give lower inter-subject variability of hippocampus CBF measurements for perfusion studies with both saline and PHY challenge. Hippocampus CBF measurements at post-bolus delay equal to 1.2 s showed the largest decrease in CBF with PHY infusion.