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Abstract #1568

Observation of Functional ADC Decrease in the Extravascular Tissue: A FMRI Study with Suppression of Intravascular Signal

Tao Jin1, Ping Wang1, Seong-Gi Kim1,2

1Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA; 2Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA

The diffusion weighted fMRI signal change has been found to increase at high b-values, indicating a decrease of the apparent diffusion coefficient (ADC). It is currently unclear whether this ADC decrease is predominately caused by vascular contributions. We have studied the diffusion-weighted fMRI in the cat visual cortex for high b-values (up to 2500s/mm2), with and without the suppression of intravascular blood using a contrast agent. We found that the diffusion fMRI signal after contrast agent injection increases with b-value at the parenchyma, indicating a small decrease of ADC in the extravascular space.