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Abstract #1599

Neurophysiological Underpinnings of Ketamine-Induced Negative BOLD Response.

Naranjargal Dashdorj1, Mirjam I. Schubert1, Malcolm Prior2, Rob Mason3, Dorothee Auer1

1Academic Radiology, University of Nottingham, Nottingham, UK; 2Brain and Body Centre, University of Nottingham, Nottingham, UK; 3School of Biomedical Sciences, University of Nottingham, Nottingham, UK

In depth understanding of drug-induced BOLD response and its underlying neural activity is essential for correct interpretation of phMRI. In this study we characterized ketamine induced BOLD signal changes in the hippocampus in a parallel electrophysiology and phMRI setup in rodent brain. Ketamine 25mg/kg i.p administration evoked both neural activity decrease (multi-unit activity and local field potential) and negative BOLD response (NBR) that was moderately correlated. To the best of our knowledge this is the first study to investigate drug-induced negative BOLD changes and its underlying neuronal activity changes. Our results suggest that drug-induced BNR reflects reduced neural activity.