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Abstract #1620

Modeling the Effect of Changes in Arterial Blood Volume on the BOLD Signal

Richard Buxton1

1University of California, San Diego, La Jolla, CA, USA

A model for the BOLD effect was extended to include the role of arterial CBV changes, and compared with the simpler Davis model that is typically used in the calibrated BOLD experiment to analyze combined CBF/BOLD data and extract an estimate of the change in CMRO2 with brain activation. Simulations indicate that the Davis model is reasonably robust, but tends to underestimate CMRO2 changes when arterial CBV changes are large. For this reason, this potential source of error cannot reconcile calibrated BOLD measurements with some PET measurements finding much smaller changes in CMRO2.