Abstract #1629

Vasoreactivity Mapping Using Dynamic (C)O2 Enhanced MRI

Stefanie Remmele¹, Julien Sngas¹, Andreas Mller², Ingobert Wenningmann³, Frank Trber², Hans Clusmann⁴, Hannes Dahnke⁵, Jrgen Gieseke⁵, Sebastian Flacke², Winfried A. Willinek², Hans H. Schild², Petra Mrtz²

¹Philips Research Europe, Hamburg, Germany; ²Department of Radiology, University of Bonn, Bonn, Germany; ³Department of Anesthesiology, University of Bonn, Bonn, Germany; ⁴Department of Neurosurgery, University of Bonn, Bonn, Germany; ⁵Philips Medical Systems, Hamburg, Germany

The dR2* response of a tumor to inhalation of O2- or CO2-enriched air is known to give insight into blood oxygenation and vasoreactivity. This work demonstrates that tumors may differ from normal tissue in the amplitude but also the temporal behavior (delay, velocity) of the response. We further propose an approach to robust dynamic (C)O2-enhanced MR measurement, analysis and depiction of the response in high-resolution vasoreactivity maps. The technique was evaluated in 5 patients with cerebral tumors.