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Abstract #1644

Impaired Thalamic Functional Connectivity in Vegetative State Detected by FcMRI

Jingsheng Zhou1,2, Chunming Xie1, Wenjun Li1, Feng Ling2, Shi-jiang Li1

1Biophysics Department, Medical College of Wisconsin, Milwaukee, WI, USA; 2Xuanwu Hospital Capital Medical University, BJ, Beijing, China

The purpose of this study is to investigate the changes of the thalamic functional connectivity (FC) network between vegetative state (VS) patients and control subjects. 5 VS patients and 4 healthy control subjects were enrolled. The averaged voxel time series from the seed Regions of Interest (bilateral thalamus) were cross-correlated with each voxel time course across the entire brain. The findings showed that FC in VS patients was significantly lower than that of control subjects in bilateral posterior cingulate cortex and precuneus.