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Abstract #1659

Meta-Analyses of Mathematical Calculation and Default-Mode Networks: Impact on BOLD-Based FMRI

Tzu-chen Yeh1,2, Tzuyi Hong2, Wen-Jui Kuo3, Jun-Ren Lee4, Chou-Ming Cheng1, Jen-Chuen Hsieh1,2, Low-Tone Ho1

1Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan; 2Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, Taiwan; 3Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan, Taiwan; 4Department of Educational Psychology and Counseling, National Taiwan Normal University, Taipei, Taiwan, Taiwan

The central correlates of mathematical calculation involved bilateral lateral parietal lobes by BOLD-based fMRI. And spatial template of the default-mode network (DMN) included extensive medial and lateral parietal lobes using independent component analysis. Interaction of calculation-relevant and DMN-modulated regions was proposed for type I error in the fMRI analysis. In this study, conjunction analysis of (1) meta-analyses using activation likelihood estimation of twelve published references of mathematical calculation, (2) spatial template of DMN and parametric fMRI results of digit naming, one-digit and two-digit addition at a 3T MRI system was applied to examine the role of lateral parietal regions.