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Abstract #1683

The Effects of Methylphenidate on Resting-State Brain Activity in Normal Adults: An FMRI Study

Biao Jiang1, Yihong Zhu1, Pingzhen Guo2, Yichao Deng1, Hongjian He1, Feiyan Chen1, Yufeng Zang3

1Zhejiang University, Hangzhou, Zhejiang, China; 2Memorial Sloan-Kettering Cancer Center , USA; 3Beijing Normal University, China

Objective:By using resting-state fMRI and analytic approach, regional homogeneity (ReHo), the study focused on the MPH effect on the intra-regional synchronization of spontensou brain activity in a group of normal adults. Methods: 1)Eighteen healthy males subjects.. 2) handedness questionnaire and the Wechsler Adult Intelligence Scale were tested. 3) After taking either MPH or placebo,the subjects were scanned a resting-state fMRI 4) The data analysis Results: MPH increases activity mainly in bilateral superior temporal lobe, right superior parietal lobe, and bilateral cuneus. MPH decreased the activity mainly in bilateral superior frontal lobes, bilateral orbital-frontal lobes, left middle frontal lobe. Conclusions: Single dose of MPH can change the resting activity in most resting-state related areas.