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Abstract #1687

Characterization of a 5-HT2C Antagonist Profile of Agomelatine Using Challenge PhMRI in the Rat

Inna Linnik1, Shane McKie2, Jennifer A. Stark3, Simon Luckman3, Bill Deakin2, Steve R. Steve R. Williams1

1Imaging Science and Biomedical Engineering, Manchester University, Manchester, UK; 2Neuroscience and Psychiatry Unit, Manchester University, Manchester, UK; 3Faculty of Life Science, Manchester University, Manchester, UK

Agomelatine is a novel clinically active antidepressant drug. The antidepressant activity of agomelatine needs the combination of melatonin agonist activity and 5-HT2C serotoninergic antagonist properties.